Journal: Neurotherapeutics

Article Title: Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning

doi: 10.1007/s13311-018-0643-2

Figure Lengend Snippet: Automated stimulation-site selection. (a) The stimulation cathode electrode is an 8-electrode linear array (1–8; 5 mm between electrodes) (OT Bioelettronica) placed across the cubital fossa to stimulate the median nerve. The anode is placed 2–3 cm proximally, avoiding the biceps muscle (to reduce muscle artifacts). The flexor carpi radialis (FCR) is recorded differentially using two standard 2.2 × 2.2-cm self-adhesive electrodes (Vermed). One recording electrode is placed over the FCR muscle belly, and the other distal to this, on the muscle/tendon junction. An algorithm cycles through each stimulation electrode using a Digitimer DS5 isolated stimulator and a digitally controlled multiplexer (Digitimer D188). (b) This produces a series of recruitment curves for each stimulation electrode. The electrode that requires the least current to elicit an H-reflex is identified (i.e., electrode 5)

Article Snippet: An algorithm cycles through each stimulation electrode using a Digitimer DS5 isolated stimulator and a digitally controlled multiplexer (Digitimer D188). ( b ) This produces a series of recruitment curves for each stimulation electrode.

Techniques: Selection, Isolation